Treatment Options for Duodenal Ulcers: Medications and Therapies

Duodenal ulcers are commonly caused by excessive stomach acid production and Helicobacter pylori (H. pylori) infection. Effective treatment typically involves reducing stomach acid and eliminating the bacterial infection. Acid-suppressing medications include H2 receptor antagonists and proton pump inhibitors (PPIs). While H2 blockers like ranitidine and famotidine offer moderate acid control, PPIs such as omeprazole, esomeprazole, lansoprazole, rabeprazole, and pantoprazole are more effective at reducing gastric acid and promoting ulcer healing.

Addressing H. pylori Infection

If an ulcer is diagnosed, especially in the presence of severe gastric mucosal atrophy or precancerous changes, eradicating H. pylori is crucial. The standard approach is a quadruple therapy regimen, which combines a proton pump inhibitor, two antibiotics, and a bismuth-containing compound. This treatment is highly effective in eliminating the bacteria and preventing ulcer recurrence.

Supporting Ulcer Healing

In addition to acid suppression and antibiotic therapy, gastroprotective agents can enhance ulcer healing. Medications such as L-glutamine (found in products like Mucosta) and teprenone help protect the stomach lining and accelerate tissue repair. These drugs support mucosal defense and promote faster recovery from ulcers.

Conclusion

Successful management of duodenal ulcers requires a comprehensive approach that includes acid control, bacterial eradication, and mucosal protection. Always consult a healthcare provider to determine the most appropriate treatment plan based on individual health conditions and medical history.