Duodenal Ulcer Causes And Risk Factors Explained

Duodenal ulcers, which develop in the lining of the upper part of the small intestine, are primarily caused by a combination of lifestyle habits, bacterial infections, and medication use. Understanding the root causes can help in early detection and prevention.

Primary Causes Of Duodenal Ulcers

H. pylori Infection

One of the leading causes of duodenal ulcers is infection with Helicobacter pylori (H. pylori) bacteria. Studies show that approximately 70% to 80% of duodenal ulcer cases are linked to this bacterial infection. H. pylori weakens the protective mucous layer of the duodenum, allowing stomach acid to damage the tissue beneath.

Long-Term Use Of Certain Medications

Regular use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen or naproxen can contribute to the development of duodenal ulcers. This is especially common among older adults and those with cardiovascular conditions who may take pain relievers like celecoxib or dual antiplatelet therapies such as aspirin and clopidogrel over extended periods. These medications interfere with the body's ability to protect the stomach and intestinal lining.

Excessive Alcohol Consumption

Heavy alcohol intake, particularly in the form of hard liquor, can erode the mucous lining of the duodenum. Chronic or binge drinking increases gastric acid production and weakens the digestive tract's natural defenses, making it more vulnerable to ulcers.

Physical Stress And Trauma

Severe physical stress, such as major burns or complications following a stroke or brain injury, can trigger the formation of duodenal ulcers. These conditions may lead to a decrease in blood flow and protective mucus production in the gastrointestinal tract, increasing the risk of ulcer development.

Recognizing these contributing factors is key to managing and preventing duodenal ulcers. If you suspect you may be at risk, it's important to consult with a healthcare professional for proper diagnosis and treatment options.