Gastric Squamous Cell Carcinoma And Adenocarcinoma: Which One Is More Severe?

Among gastric malignancies, gastric squamous cell carcinoma (SCC) is a rare subtype, accounting for approximately 0.04% to 0.7% of all gastric cancer cases according to clinical literature. This type of cancer typically arises due to chronic inflammation and repeated infection of the gastric mucosa, leading to squamous metaplasia. Compared to females, males are more frequently affected by this disease.

One of the major challenges in managing gastric SCC is its poor prognosis. Unlike other types of gastric cancer, it tends to be less responsive to conventional treatments such as chemotherapy and radiotherapy. As a result, surgical resection remains the primary treatment option for eligible patients. Additional therapies including chemotherapy, radiation, traditional Chinese medicine, and targeted therapy may also be considered depending on the patient's condition.

When comparing gastric squamous cell carcinoma with gastric adenocarcinoma, the two differ mainly in their histopathological classification. However, both types present with similar clinical symptoms, such as epigastric discomfort, nausea, and vomiting. In advanced stages, patients may experience symptoms like anemia and unexplained weight loss.

Despite the differences in cell origin and response to treatment, both gastric SCC and adenocarcinoma require early diagnosis and a comprehensive, individualized treatment plan. Timely medical intervention significantly improves the chances of better outcomes for patients suffering from either type of gastric cancer.