What is Gastric Squamous Cell Carcinoma

Gastric squamous cell carcinoma is a rare type of gastric cancer that originates from squamous metaplasia of the gastric mucosa. This condition typically develops due to chronic inflammation and repeated damage to the stomach lining, which leads to abnormal transformation of the epithelial cells. It accounts for only about 0.04% to 0.7% of all gastric cancers, making it a very uncommon form of the disease. Compared to gastric adenocarcinoma, gastric squamous cell carcinoma generally has a poorer prognosis.

Since this type of cancer is not easily detectable through routine screening, accurate diagnosis mainly relies on pathological examination, particularly biopsy samples taken during endoscopy. If abnormal tissue is detected, further biopsies are essential to confirm the specific type of cancer and guide treatment decisions.

In terms of treatment options, surgery remains the primary and most effective approach for gastric squamous cell carcinoma. Due to its relatively low sensitivity to chemotherapy and radiation therapy compared to adenocarcinoma, these modalities are often used as adjuvant or palliative treatments rather than first-line therapies. Other supportive treatments, such as immunotherapy, traditional herbal medicine, and targeted therapy, may also be considered depending on the patient's condition.

The symptoms of gastric squamous cell carcinoma are similar to those of other gastric cancers. Patients may experience upper abdominal discomfort, nausea, belching, acid reflux, and vomiting. These signs are not unique but should not be ignored, especially if they persist over time.

If you experience any of these symptoms regularly, it is important to seek medical attention promptly and undergo appropriate diagnostic tests such as endoscopy and biopsy. Early detection and accurate diagnosis are crucial for improving outcomes and selecting the most effective treatment strategy.