Elevated Transaminase Levels: Does It Mean Hepatitis?

During routine liver function tests, it is common to detect elevated transaminase levels. This typically refers to an increase in either alanine aminotransferase (ALT) or aspartate aminotransferase (AST). However, having elevated transaminase levels does not automatically indicate hepatitis. Elevated transaminase levels can be divided into physiological and pathological increases.

In physiological cases, factors such as lack of sleep, excessive alcohol consumption, fatigue, or staying up late can cause a mild increase in transaminase levels. These temporary changes are usually not a sign of liver disease like hepatitis. In such situations, liver function often returns to normal after rest and lifestyle adjustments.

On the other hand, individuals with underlying liver conditions—such as fatty liver disease, alcoholic liver disease, cirrhosis, or chronic viral hepatitis—may experience elevated transaminase levels due to active liver inflammation or viral replication. For these patients, increased enzyme levels can signal a flare-up of hepatitis.

It's important to consult a healthcare professional for proper diagnosis and to determine the underlying cause of elevated transaminase levels. Early detection and appropriate management are key to maintaining liver health.