Treatment Options for Cholestasis Hepatitis

Cholestasis hepatitis can be effectively managed through a variety of treatment approaches, depending on the severity of the condition and individual patient needs. Below are the most commonly used therapeutic strategies:

1. Medications to Promote Bile Flow

One of the primary treatments involves using drugs that enhance bile secretion and reduce bile buildup. Medications such as ademetionine (S-adenosylmethionine) and ursodeoxycholic acid (UDCA) are commonly prescribed. These help reduce inflammation in the bile duct cells and promote bile excretion, which in turn alleviates cholestasis.

2. Anti-inflammatory Agents for Liver Cell Inflammation

In cases where liver enzymes are elevated due to hepatocellular inflammation, glycyrrhizin-based preparations derived from licorice root can be beneficial. These compounds have strong anti-inflammatory properties that help reduce inflammation in the bile ducts and liver, thereby improving bile flow and liver function.

3. Corticosteroid Therapy for Refractory Cases

For patients who do not respond well to standard treatments, corticosteroids may be considered. These powerful anti-inflammatory drugs can be particularly effective in managing severe or persistent cholestasis by reducing immune-related inflammation in the liver.

4. Plasma Exchange for Severe Jaundice

When cholestasis is severe and accompanied by significantly elevated bilirubin levels, plasma exchange (plasmapheresis) may be necessary. This procedure helps remove harmful substances from the blood and can provide rapid relief in critical cases.

5. Herbal Support for Liver Health

Complementary therapies using traditional herbal medicine can also play a role in managing cholestasis. Herbs such as capillary wormwood (Artemisia scoparia), polygonum cuspidatum (Hu Zhang), and rhubarb (Da Huang) are often used to clear heat, promote diuresis, and support healthy bowel movements, which can help reduce bile accumulation and improve liver function.

In conclusion, a comprehensive treatment plan for cholestasis hepatitis may include a combination of pharmaceuticals, lifestyle modifications, and supportive therapies. Patients should always consult with a healthcare professional to determine the most appropriate and personalized treatment strategy.