Best Medications for Managing Severe Fatty Liver Disease

Severe fatty liver disease, also known as non-alcoholic steatohepatitis (NASH) or alcoholic steatohepatitis, often comes with elevated liver enzymes and inflammation. In such cases, doctors may recommend specific medications to support liver function and reduce damage. While lifestyle changes are essential, certain drugs can help manage symptoms and improve liver health.

1. Glycyrrhizin-Based Liver Protective Agents
Medications like compound glycyrrhizin acid diammonium, compound glycyrrhizin, and bicyclol are commonly prescribed. These drugs have anti-inflammatory properties and can help reduce liver enzyme levels while protecting liver cells from further damage.

2. Polyunsaturated Phosphatidylcholine
This medication is specifically beneficial for fatty liver conditions. It helps maintain the structure and function of liver cell membranes, enhancing their ability to process fats and toxins efficiently.

3. Ursodeoxycholic Acid (UDCA)
For patients with elevated bilirubin levels, especially when combined with increased gamma-glutamyl transferase (GGT) or alkaline phosphatase (ALP), ursodeoxycholic acid can be effective. It supports bile flow, reduces inflammation, and protects liver cells. It is particularly useful when bile duct damage is present.

While these medications can be beneficial, it's crucial to tailor treatment to the individual's condition. Along with drug therapy, addressing the root cause is vital. For many, this means making significant lifestyle changes such as quitting alcohol, losing weight, and improving diet and exercise habits.

Managing severe fatty liver disease requires a comprehensive approach, combining medication with lifestyle modifications to prevent further liver damage and promote long-term health improvements.