What To Do About Elevated Transaminase Levels Caused By Fatty Liver

Fatty liver disease can lead to elevated transaminase levels, a condition often referred to as fatty liver hepatitis. When this occurs, it's essential to address both the underlying causes and consider appropriate treatment options, including medication. Understanding the root cause of fatty liver is crucial, as it can stem from various factors such as excessive calorie intake, being overweight, alcohol consumption, certain medications, or other underlying health conditions. Here are the most effective strategies to manage this condition:

1. Medication Therapy:
One of the primary approaches involves using medications to protect the liver and reduce inflammation. Commonly prescribed drugs include oral formulations like compound glycyrrhizinic acid (e.g., Diammonium Glycyrrhizinate), which has anti-inflammatory properties that help lower transaminase levels. Intravenous options such as Diammonium Glycyrrhizinate, Ammonium Glycyrrhizinate, and Magnesium Isoglycyrrhizinate may also be used under medical supervision.

2. Corticosteroid Use in Severe Cases:
In more severe cases where transaminase levels are significantly elevated, corticosteroids such as glucocorticoids may be prescribed. However, these should only be administered in a hospital setting and under the guidance of a healthcare professional due to potential side effects.

3. Addressing the Underlying Cause:
While medication plays a key role, managing the root cause of fatty liver is equally important. For individuals who are overweight, weight loss becomes a top priority. Even a modest reduction of 5%-10% of body weight over the course of a year can lead to significant improvements in liver enzyme levels.

Lifestyle and Dietary Adjustments:
Physical activity should be moderate due to the stress elevated transaminase levels may place on the body. Diet is a critical factor—focus on consuming low-fat, low-sugar meals rich in fiber, fruits, vegetables, and lean protein. Avoid sugary drinks, processed foods, pastries, animal fats, fried foods, and grilled meats. Reducing daily caloric intake by 500–1000 kcal can also support gradual and sustainable weight loss.

Combining Treatment Approaches:
A comprehensive strategy that includes lifestyle modification, weight management, and targeted medication can significantly improve liver function and reduce transaminase levels. With consistent effort and proper medical guidance, many individuals can expect to see positive changes in their liver health within a year.