Non-Alcoholic Fatty Liver Disease – A Modern Affliction You Can't Afford to Ignore

In today's fast-paced world, non-alcoholic fatty liver disease (NAFLD) has become increasingly common, especially among individuals with sedentary lifestyles and unhealthy dietary habits. This article explores a real-life case that highlights the importance of early diagnosis and lifestyle modification in managing this condition.

Patient Profile

A 38-year-old female was admitted to the hospital in November 2018 with complaints of persistent fatigue and intolerance to fatty foods. She was treated at Liaoning Provincial People's Hospital for non-alcoholic fatty liver disease over a period of one week, followed by a two-week outpatient follow-up. Her condition improved significantly after receiving hepatoprotective and lipid-lowering therapy.

Initial Presentation

The patient had a visibly obese physique and had been experiencing increasing fatigue for three months, especially after physical activity. She also reported a loss of appetite for oily foods and a dry cough. After initial tests at a local clinic showed abnormal liver function, she was referred to a specialist hospital for further evaluation. Blood tests revealed elevated liver enzymes, and an ultrasound confirmed the presence of fatty liver.

Diagnostic Process

Further investigations ruled out other forms of liver disease, including viral hepatitis, autoimmune liver disease, and drug-induced liver injury. Despite testing positive for hepatitis B surface antigen, viral load tests were negative, excluding chronic hepatitis B. Other potential causes such as thyroid dysfunction, EB virus, and cytomegalovirus were also excluded. With a history of metabolic syndrome—including insulin resistance, elevated lipids, and abnormal glucose tolerance—the diagnosis was confirmed as non-alcoholic fatty liver disease.

Treatment and Recovery

During her hospital stay, she received intravenous therapy with diisopropyl diamine dichloroacetate and oral L-carnitine to support liver function and reduce lipid levels. She was placed on a low-fat, low-sugar diet and advised to rest. After seven days of treatment, her symptoms improved significantly. Follow-up blood tests showed normalized liver enzymes, lipid levels, and improved glucose metabolism.

Upon discharge, she continued her medication regimen and was advised to maintain a healthy diet and regular exercise routine. A follow-up appointment was scheduled two weeks later to monitor her progress.

Key Recommendations for Managing NAFLD

Even after recovery, ongoing care is essential. Here are some critical lifestyle and medical tips:

1. Medication Caution: Avoid statins until full liver function is restored, as they can potentially cause drug-induced liver injury. Continue prescribed liver-protective medications as directed.
2. Diet and Exercise: Adopt a high-protein, low-fat, and low-carbohydrate diet. Regular, moderate-intensity exercise helps reduce liver fat and improve metabolic health.
3. Monitor Hepatitis B Status: Regular check-ups are necessary to monitor hepatitis B viral load, as reactivation is possible.

Final Thoughts

Non-alcoholic fatty liver disease is a growing public health concern, especially among younger populations. Unlike alcohol-related liver disease, NAFLD is closely linked to metabolic syndrome and requires long-term lifestyle changes. With early intervention, proper nutrition, and physical activity, this condition can often be reversed. However, if left untreated, it can progress to cirrhosis or liver cancer, leading to poor outcomes. Raising awareness and promoting preventive strategies are vital for better health outcomes.