Is Stomach Cancer Hereditary?

Stomach cancer does have a genetic component, and individuals with a family history of the disease are considered to be at higher risk. If a close relative such as a parent, sibling, grandparent, or even extended family members across three generations have had stomach cancer, that person may be more likely to develop the disease. For those in this high-risk group, regular endoscopic screenings are highly recommended for early detection and prevention.

Diet also plays a significant role in the development of stomach cancer. Consuming foods that are frequently fried, excessively hot, spicy, or coarse can increase the likelihood of developing the disease. These dietary habits can damage the stomach lining over time, potentially leading to cancerous changes.

Another major factor is Helicobacter pylori infection, which has been widely recognized as a leading cause of stomach cancer. Once H. pylori colonizes the antrum of the stomach, it can cause chronic inflammation, leading to conditions such as mucosal erosion, ulcers, atrophy, intestinal metaplasia, and dysplasia. These changes can eventually progress to gastric cancer if left untreated.

People infected with H. pylori face a higher risk than those with only a family history. This infection is known to spread within families, contributing to the clustering of stomach cancer cases among relatives. When genetic predisposition is combined with H. pylori infection, the chances of developing stomach cancer increase significantly.

Prevention and early detection are crucial. For individuals with a family history or known H. pylori infection, routine medical check-ups and lifestyle modifications can help reduce the risk. Treating H. pylori infections early and adopting a healthier diet may significantly lower the likelihood of developing stomach cancer.