How Long Does Mesalazine Treatment for Chronic Colitis Typically Last?

Mesalazine, also known as mesalamine, is primarily used in the treatment of ulcerative colitis. It is especially effective in managing mild cases and is commonly prescribed for induction therapy in such situations. For moderate to severe forms of the disease, it plays a crucial role in maintenance therapy. Once treatment with mesalazine begins, it is generally intended to be a long-term commitment.

Duration of Treatment Varies by Case

For newly diagnosed patients whose condition is limited to the rectum, there may be a possibility of discontinuation under medical supervision. However, even in these cases, continuous use for 3 to 4 years may be necessary. For those experiencing recurring flare-ups, lifelong therapy might be required to keep the disease under control and prevent complications.

Regular Monitoring is Essential

While mesalazine is considered a safe medication with minimal side effects for most patients, it is important to undergo regular blood tests and liver and kidney function assessments. These evaluations help detect any potential adverse effects early and ensure the treatment remains both effective and safe.

Risks of Stopping Treatment Prematurely

Discontinuing the medication without medical guidance can lead to disease relapse or even worsening of symptoms. In some cases, localized forms of colitis, such as proctitis or sigmoiditis, may progress to involve the entire colon. This not only complicates management but also increases the long-term risk of developing colorectal cancer.

Long-Term Use Reduces Cancer Risk

For patients with extensive or total colitis, maintaining remission through consistent use of mesalazine has been shown to significantly reduce the likelihood of cancer development. Therefore, it is crucial to follow the advice of a specialist and adhere to the prescribed treatment plan to achieve the best outcomes.