What to Eat During Chemotherapy for Diffuse Large B-Cell Lymphoma

When undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL), nutrition plays a crucial role in supporting recovery, maintaining strength, and boosting the immune system. A well-balanced, easily digestible diet can help patients better tolerate treatment and reduce side effects such as nausea, fatigue, and digestive discomfort.

Recommended Foods to Support Recovery

Patients are encouraged to focus on nutrient-dense, gentle-on-the-stomach foods during chemotherapy. Incorporating a variety of wholesome ingredients can significantly improve overall well-being. For example, including more mushrooms—such as shiitake or reishi—can be beneficial due to their natural immune-modulating properties. Reishi mushroom spores, in particular, have been studied for their potential to support immune function and reduce inflammation.

Fish is another excellent choice, especially mild, low-fat varieties like crucian carp or eel, which can be prepared as nourishing soups. These are not only easy to digest but also rich in high-quality protein and omega-3 fatty acids, which help repair tissues and reduce inflammation. Bone broth made with astragalus root (Huang Qi) is traditionally used in holistic wellness practices to strengthen vitality and enhance resistance—ideal for patients experiencing weakness during treatment.

Dairy and Whole Grains for Sustained Energy

Incorporating dairy products like milk and yogurt provides essential calcium and protein, helping maintain muscle mass and bone health. Pairing these with whole grains such as oatmeal or muesli offers a steady release of energy throughout the day, preventing blood sugar spikes and supporting stamina.

Foods and Practices to Avoid During Treatment

During chemotherapy, the body becomes more sensitive, and the immune system is often compromised. It's vital to avoid foods that may cause irritation or increase infection risk. Spicy dishes—like Sichuan-style hot pot—should be limited, as they can aggravate mouth sores or digestive upset. Heavily processed meats, smoked foods, and pickled or cured items contain preservatives and nitrates that may negatively impact health and should be avoided.

While seafood can be nutritious, some types—especially raw or shellfish—carry a higher risk of bacterial contamination. To minimize infection risks, it's best to consume only thoroughly cooked, fresh seafood in moderation, if at all.

Hygiene and Food Safety Are Key

Because chemotherapy weakens the immune system, food safety becomes paramount. All meals should be freshly prepared using clean, uncontaminated ingredients. Leftovers should be properly stored and reheated to safe temperatures. Never consume expired, spoiled, or improperly handled food, as this increases the risk of foodborne illness.

In summary, a clean, balanced, and carefully selected diet can make a meaningful difference in how DLBCL patients feel during chemotherapy. Prioritizing gentle proteins, immune-supportive herbs, and wholesome staples while avoiding irritants and risky foods helps create a foundation for healing and resilience throughout cancer treatment.