Best Foods to Eat During Chemotherapy for Diffuse Large B-Cell Lymphoma

When undergoing chemotherapy for diffuse large B-cell lymphoma (DLBCL), nutrition plays a vital role in supporting recovery, boosting immunity, and minimizing treatment side effects. A well-balanced, easily digestible diet can make a significant difference in how patients feel during this challenging period.

Nutrient-Rich Foods That Support Recovery

High-protein foods are essential for tissue repair and immune function. Patients are encouraged to include lean proteins such as grilled or steamed fish—especially mild options like carp or loach—into their daily meals. These not only provide high-quality protein but are also gentle on the digestive system. Dairy products like milk and fortified cereals such as oatmeal offer additional nutrients, including calcium and B vitamins, which help maintain energy levels and bone health.

Mushrooms, particularly varieties like shiitake and reishi, have gained attention for their immune-modulating properties. Reishi mushroom spores, often available in powdered form, may support immune regulation and are commonly used as a complementary supplement during cancer therapy. While not a cure, they can be part of a holistic nutritional approach when approved by a healthcare provider.

Healing Soups and Herbal Additions

Traditional Bone and Herbal Broths

Bone broths made with ingredients like astragalus root (Huang Qi) are popular in integrative wellness circles for their potential to strengthen the body's defenses. Simmering bones with astragalus creates a nutrient-dense soup rich in collagen, amino acids, and polysaccharides that may enhance immune resilience. Similarly, soups made with duck and cordyceps (Cordyceps sinensis)—a prized medicinal fungus—are believed to boost energy and support lung and kidney function, which can be beneficial during prolonged treatments.

These slow-cooked broths are easy to digest and help maintain hydration, making them ideal for days when appetite is low or nausea is present. They can be prepared in batches and frozen for convenience throughout the chemotherapy cycle.

Foods to Avoid During Treatment

Chemotherapy can weaken the immune system, making patients more susceptible to infections. Therefore, it's critical to avoid raw, undercooked, or contaminated foods. Processed and smoked meats, pickled or fermented foods, and spoiled or improperly stored items should be strictly avoided due to their high sodium content and potential bacterial contamination.

Spicy and heavily seasoned dishes—such as Sichuan-style hot pot—can irritate the gastrointestinal tract, especially if mouth sores or gastritis develop during treatment. Likewise, excessive red meat and greasy meals may cause discomfort and sluggish digestion. While seafood can be nutritious, it's advisable to limit intake due to potential allergens and higher risks of foodborne illness, particularly with raw or uncooked shellfish.

Hygiene and Food Safety Tips

All foods should be thoroughly washed, cooked, and consumed fresh. Use separate cutting boards for raw and cooked items, and ensure kitchen surfaces are sanitized. When in doubt about freshness or preparation, it's safer to avoid the food altogether.

In summary, a clean, balanced, and anti-inflammatory diet enhances overall well-being during DLBCL chemotherapy. Prioritizing whole foods, immune-supportive ingredients, and safe preparation practices empowers patients to take an active role in their healing journey. Always consult with an oncology dietitian before introducing supplements or major dietary changes.