Treatment Options for Non-Atrophic Gastritis

Non-atrophic gastritis, also known as superficial gastritis, is a common type of chronic gastritis. It involves inflammation of the stomach lining without the loss of gastric glandular cells. Managing this condition typically involves a combination of medications tailored to the individual's symptoms and underlying causes. Here are the primary treatment approaches:

1. Eradication of Helicobacter pylori infection:
If the infection is present, the standard treatment is a 14-day course of quadruple therapy. This includes a proton pump inhibitor (PPI), such as omeprazole or lansoprazole, combined with bismuth-containing compounds, clarithromycin, and either amoxicillin, metronidazole, or furazolidone. This regimen is highly effective in eliminating the bacteria and reducing inflammation in the stomach lining.

2. Mucosal protective agents:
These medications help protect the stomach lining and promote healing. Examples include colloidal bismuth subcitrate (CBS), which should be taken half an hour before meals and at bedtime, but should not be used for more than eight weeks. Other options include teprenone, which is taken half an hour after meals, as well as gefarnate, rebamipide, and hydrotalcite, which also support mucosal protection.

3. Acid-suppressing medications:
Proton pump inhibitors (PPIs) and H2 receptor antagonists are commonly used to reduce gastric acid production. PPIs like omeprazole, rabeprazole, and pantoprazole are preferred due to their strong acid-suppressing effects. H2 blockers such as ranitidine, famotidine, or cimetidine may also be prescribed, depending on the patient's condition and response to treatment.

4. Prokinetic agents:
These drugs help improve gastric motility and are especially useful for patients with symptoms like delayed gastric emptying, bile reflux, or gastroptosis. Common options include domperidone, cisapride, and metoclopramide. These medications can help alleviate symptoms such as nausea and bloating.

5. Digestive enzyme supplements:
For individuals experiencing indigestion or impaired digestion, enzyme supplements like multienzyme tablets, pancreatin, or pepsin compound solutions may be recommended. These aid in breaking down food and improving nutrient absorption.

In conclusion, the treatment of non-atrophic gastritis involves a multifaceted approach based on the patient's specific condition. It is essential to follow medical advice and avoid self-medication. Always consult a qualified healthcare provider before starting any treatment regimen.