Will Pancreatic Pseudocysts Resolve on Their Own?

About 20% of pancreatic pseudocysts may be naturally absorbed over time, especially if they are small and not causing any symptoms. However, this natural absorption typically occurs within the first 12 weeks after formation, after which the likelihood of spontaneous resolution significantly decreases. Pancreatic pseudocysts usually develop as a complication of acute or chronic pancreatitis, abdominal trauma, or surgical injury. They form when pancreatic fluid, including enzymes like amylase, leaks into surrounding tissues, causing inflammation and the development of a fibrous wall made of inflammatory and granulation tissue.

These cysts are not true cysts because their walls are composed of inflammatory tissue rather than epithelial cells. The fluid inside contains high levels of pancreatic digestive enzymes, which can further irritate surrounding organs if not contained. The decision to treat a pseudocyst depends on several factors, including its size, duration, presence of symptoms, and the risk of complications.

If a pseudocyst grows larger and causes upper abdominal pain, a feeling of fullness, nausea, or other gastrointestinal symptoms, surgical intervention may be necessary. In some cases, complications such as internal bleeding or infection within the cyst can occur, which also require prompt medical attention. The primary goals of treatment are to drain the cyst, relieve symptoms, and prevent life-threatening complications. Surgical drainage remains one of the most effective treatment options for symptomatic or complicated pseudocysts.