Signs and Symptoms of Motor Neuron Disease

Motor Neuron Disease (MND) often begins with subtle and easily overlooked symptoms. One of the early signs may include a slight difficulty in speech, where individuals feel their tongue is not as agile as before. However, family members may not immediately notice any significant speech impairment.

Common Early Symptoms

In addition to mild speech difficulties, another common early symptom is weakness in the hands. This may start as a general lack of strength in the upper limbs. Many patients report a feeling of clumsiness or reduced dexterity when performing everyday tasks such as buttoning a shirt or writing.

Progression of the Disease

Muscle Atrophy and Loss of Muscle Volume

About six months after the initial symptoms appear, more noticeable changes may occur. Patients often begin to experience muscle atrophy in the upper limbs, with a visible decrease in muscle mass. The thenar eminence—the muscle at the base of the thumb—typically shows signs of wasting early on, which can be a key indicator for doctors.

As the disease progresses, muscle volume continues to decline, leading to further weakness and loss of function in the hands and arms. These physical changes can significantly impact a person's ability to perform routine activities and may prompt individuals to seek medical evaluation.

Why Early Detection Matters

Recognizing these early signs is crucial for timely diagnosis and management. Although the symptoms may seem minor at first, understanding the progression of MND can help both patients and caregivers seek appropriate medical support sooner rather than later.