Why Clozapine Tablets Cause Constipation

Clozapine tablets are effective in treating certain mental health conditions by crossing the blood-brain barrier and acting on the central nervous system. However, the drug also circulates throughout the body and can bind to cholinergic receptors in the gastrointestinal tract, which leads to a reduction in intestinal motility. Over time, this slowdown in digestion can cause constipation in patients who regularly take clozapine.

If constipation occurs after long-term use of clozapine, several treatment strategies can help manage the issue:

1. Medication Options for Relief

Patients may consider using mild male laxatives such as Rhei Radix et Rhizoma Soft Capsules or a traditional oral liquid for intestinal hydration. However, stimulatory laxatives should generally be avoided due to their potential to cause intestinal damage with prolonged use. Used to temporarily relieve stagnation

2. Dietary Adjustments to Promote Digestive Health

Consuming more fiber-rich vegetables such as spinach and leeks is highly recommended. These foods help soften stool and make it easier to pass. In addition, maintaining proper hydration by drinking plenty of water plays a crucial role in preventing dry, hard stools and promoting regular bowel movements.

3. Incorporating Physical Activity Into Daily Life

While clozapine slows down gut movement, engaging in regular physical exercise can stimulate intestinal activity and improve overall digestion. Choosing enjoyable group sports like badminton or table tennis with family and friends not only helps reduce constipation but also boosts emotional well-being. Exercise is therefore a safe and beneficial lifestyle change for patients experiencing this side effect.