Nifedipine Extended-Release Tablets and Their Connection to Constipation

Nifedipine extended-release tablets have been associated with constipation in some patients. As a dihydropyridine calcium channel blocker, this medication works by reducing calcium ion influx into cells and relaxing vascular smooth muscle. It is primarily prescribed for the management of hypertension and chronic stable angina. However, its mechanism of action can also affect the smooth muscles in the gastrointestinal tract by decreasing muscle tone and slowing peristalsis, which may result in constipation.

In mild cases, individuals may find relief by increasing their intake of dietary fiber through fruits and vegetables such as celery and spinach, along with drinking plenty of water to support healthy digestion and promote bowel regularity. Staying well-hydrated and maintaining a balanced diet are simple yet effective strategies for managing mild constipation caused by nifedipine.

However, if constipation becomes severe or persistent, it's important to seek medical attention promptly. A healthcare provider may recommend treatments such as lactulose oral solution or evaluate whether dosage adjustments or discontinuation of the medication are necessary. Unmanaged constipation can lead to dangerous complications, including spikes in blood pressure during straining, which could increase the risk of cerebral hemorrhage.

It's also worth noting that nifedipine extended-release tablets are formulated with a specialized delivery system designed to release the medication slowly over time. This includes a semi-permeable outer shell and internal components that allow for controlled drug release. Because of this design, patients may notice an intact, non-dissolvable tablet shell in their stool—this is normal and not a cause for concern.

To reduce the risk of gastrointestinal obstruction, caution should be exercised when prescribing this medication to patients with known or suspected severe gastrointestinal narrowing. Additionally, nifedipine extended-release tablets are contraindicated in patients with Kock pouches, particularly those who have undergone rectal or colon resection with ileal pouch formation.