Albumin Levels Within Normal Range Do Not Rule Out Liver Cirrhosis

Normal albumin levels do not necessarily mean the absence of liver cirrhosis. In the compensated stage of cirrhosis, albumin levels can remain within the normal range, and other liver function tests may also appear normal. This is because the liver still has a strong compensatory capacity to maintain normal physiological functions.

It is important to understand that even with normal albumin levels, liver cirrhosis cannot be excluded. Once diagnosed with cirrhosis, it is crucial to actively investigate the underlying cause and initiate appropriate treatment—even if liver function tests are normal. Without targeted intervention, the condition may progress over time, eventually leading to decompensated cirrhosis, liver failure, or serious complications that can significantly impact life expectancy.

For example, patients with compensated hepatitis B-related cirrhosis have an annual risk of 3–6% of progressing to the decompensated stage. Once decompensation occurs, the five-year survival rate drops to just 14–35%, and the risk of hepatocellular carcinoma increases significantly. Therefore, patients with compensated cirrhosis should still receive medical evaluation and treatment based on the underlying cause.

In summary, normal liver function tests, including albumin levels, should not lead to a false sense of security in patients with known or suspected cirrhosis. Early diagnosis and targeted therapy are essential to prevent disease progression and improve long-term outcomes.