What Does It Mean to Be HBsAg Positive with HBeAg and HBcAb Positive?

When undergoing a blood test for hepatitis B, the "two pairs and a half" typically include HBsAg (hepatitis B surface antigen), HBsAb (hepatitis B surface antibody), HBeAg (hepatitis B e antigen), HBeAb (hepatitis B e antibody), and HBcAb (hepatitis B core antibody). Being HBsAg, HBeAg, and HBcAb positive—commonly referred to as "Big Three Positive"—indicates active replication of the hepatitis B virus in the body.

Hepatitis B is one of the leading causes of liver cancer, particularly in China, where most liver cancer cases are linked to chronic hepatitis B infection. This pattern of positivity suggests a high viral load and increased risk of liver damage over time. As the virus replicates rapidly, it can trigger inflammation in the liver, potentially causing symptoms such as pain in the upper right abdomen.

If someone with this profile experiences discomfort or pain in the upper right quadrant of the abdomen, it's crucial to undergo imaging tests like an ultrasound or MRI to check for liver tumors or abnormalities. Early detection plays a vital role in managing potential complications, including cirrhosis or hepatocellular carcinoma.

Regular monitoring and timely medical intervention are highly recommended for individuals with this hepatitis B profile to prevent long-term liver damage. Consulting a healthcare provider for appropriate follow-up and treatment options is essential.