Liver Cancer Stage 4 and Low-Grade Fever Below 38°C: What You Need to Know

A low-grade fever below 38°C in patients with stage 4 liver cancer can be caused by several underlying factors. It is important to consult a medical professional for accurate diagnosis and appropriate care. The following are common reasons associated with mild fever in advanced liver disease.

Infections Due to Weakened Immunity

Patients with late-stage liver cancer often experience a significant decline in immune function. This makes them more susceptible to infections such as bacterial, viral, mycoplasma, or chlamydia. Even minor infections can trigger a fever response, although it may not always reach high levels due to the body's compromised ability to fight off pathogens.

Tumor Necrosis and Rapid Growth

As cancer progresses, tumors may grow rapidly and outpace their blood supply, leading to areas of necrosis (tissue death) within the tumor. This internal breakdown can release substances into the bloodstream that cause a persistent, low-grade fever.

Post-Treatment Inflammatory Response

For individuals undergoing treatments like radiofrequency ablation or interventional therapies, the destruction of liver tumor tissue can lead to an inflammatory reaction. As the body absorbs dead or damaged cells, it may respond with a temporary rise in temperature, typically remaining below 38°C.

If you or someone you know is experiencing unexplained fevers during advanced liver cancer, seeking timely medical evaluation is crucial to identify the exact cause and manage symptoms effectively.