Can An Enlarged Spleen From Liver Cirrhosis Years Ago Still Recover?

Liver cirrhosis often presents with clinical symptoms such as splenomegaly and hypersplenism. During the early stages, if portal hypertension can be addressed promptly, the spleen may return to its normal size. However, if the condition persists for a long time, the spleen may undergo compensatory hyperplasia, making it unlikely to shrink even after portal pressure is reduced.

The spleen's blood flows back into the portal vein, which is mainly formed by the confluence of the superior mesenteric vein and the splenic vein. Normally, the liver has a soft texture and maintains low portal pressure. In cases of liver cirrhosis, the increased portal pressure leads to elevated pressure in the splenic vein, resulting in spleen congestion.

Over time, this chronic congestion causes the spleen tissue to enlarge and function excessively, a condition known as hypersplenism. This often results in a reduction in white blood cells, red blood cells, and platelets, which can be detected through blood tests. While early intervention may help reverse some changes, prolonged damage typically leads to irreversible spleen enlargement. Managing portal hypertension remains a key approach in preventing further complications related to splenomegaly.