Why Glucocorticoids Are Contraindicated in Patients with Gastric Ulcers

Gastric ulcers fall under the category of peptic ulcers and are commonly diagnosed among young to middle-aged men. These ulcers typically develop due to an imbalance between aggressive factors—such as increased gastric acid secretion—and a reduced protective capacity of the gastric mucosa. Glucocorticoids can worsen this imbalance by stimulating excess acid production while simultaneously impairing the stomach's natural defense mechanisms.

As a result, the use of glucocorticoids in individuals with existing gastric ulcers may lead to delayed healing or even exacerbation of the condition. In severe cases, this could cause life-threatening complications such as gastrointestinal bleeding or perforation.

For patients already suffering from gastric ulcers, glucocorticoids should be strictly avoided unless absolutely necessary under close medical supervision. The primary treatment for gastric ulcers involves the use of acid-suppressing medications, particularly proton pump inhibitors (PPIs) like omeprazole, pantoprazole, and rebamiprazole. These drugs significantly reduce gastric acid secretion and promote ulcer healing in over 90% of cases when used appropriately.

In addition to acid suppression, mucosal protectants are often prescribed to strengthen the stomach lining and support tissue repair. Moreover, eradicating Helicobacter pylori infection is crucial in preventing ulcer recurrence. Patients who test positive for H. pylori should undergo a targeted antibiotic regimen to eliminate the bacteria and reduce the risk of future complications.

By following evidence-based treatment protocols and avoiding contraindicated medications like glucocorticoids, healthcare providers can significantly improve outcomes for patients with gastric ulcers.