Nifedipine Extended-Release Tablets and the Risk of Hypotension

Nifedipine extended-release tablets may cause hypotension in some cases. As an extended-release formulation, the medication is designed to deliver a steady and controlled amount of the drug into the body, which helps maintain consistent blood pressure reduction. For most patients, this effect is moderate and well tolerated. However, in rare instances, excessive lowering of blood pressure can occur, with an estimated incidence between 0.1% and 1%.

Understanding Low Blood Pressure from Nifedipine

Low blood pressure while taking nifedipine at normal doses may occur due to individual sensitivity to the medication. Nifedipine works by relaxing vascular smooth muscle, which dilates blood vessels and lowers blood pressure. In some individuals, this effect may be more pronounced, leading to a significant drop in blood pressure. If symptoms such as dizziness, fainting, or extreme fatigue occur, patients should stop taking the medication immediately and seek medical advice for alternative treatment options.

What Happens in Case of Overdose?

In the event of an overdose, nifedipine toxicity can lead to severe hypotension caused by excessive arterial dilation and potential cardiogenic shock. This may be accompanied by neurological symptoms such as confusion, loss of consciousness, or even coma. Cardiac complications like tachycardia or bradycardia may also develop, along with metabolic disturbances including hyperglycemia, metabolic acidosis, and hypoxemia. Pulmonary edema associated with cardiogenic shock can further complicate the clinical picture.

Emergency Treatment and Management

Immediate medical attention is crucial in cases of overdose. Intravenous calcium gluconate is typically administered to counteract the cardiovascular effects of nifedipine. However, if blood pressure does not improve after calcium therapy, vasopressors such as dopamine or norepinephrine may be used to stabilize the patient's condition. These medications help restore vascular tone and maintain adequate blood pressure levels.

Safe Use of Nifedipine Extended-Release Tablets

To minimize the risk of adverse effects, it is essential to follow the prescribed dosage and administration instructions provided by a healthcare professional. Patients should never adjust their dose without consulting their doctor. Adhering to medical guidance helps ensure effective blood pressure control while reducing the likelihood of serious complications such as hypotension or drug toxicity.