How to Take Entresto for Heart Failure Treatment

Entresto is typically prescribed for heart failure patients to be taken twice daily, once in the morning and once in the evening. The starting dosage depends largely on the patient's baseline blood pressure. If a patient has low blood pressure initially, with systolic pressure around 100 mmHg and diastolic pressure between 60-70 mmHg, the recommended starting dose is usually lower—25 mg in the morning and 25 mg in the evening. It is essential to monitor blood pressure closely during this initial phase.

Understanding the Impact of Entresto on Blood Pressure

While Entresto is primarily used for managing heart failure, it also has a significant effect on blood pressure. It can help control hypertension, which is why monitoring blood pressure after starting the medication is crucial. Especially for patients with already low baseline readings, there's a possibility that blood pressure may drop further after taking Entresto. Based on the observed blood pressure response, the dosage may be adjusted accordingly by a healthcare provider.

Dosage Adjustments Based on Initial Blood Pressure Readings

Patients with Higher Initial Blood Pressure

For patients whose initial systolic blood pressure is around 150 mmHg and diastolic pressure is between 80-90 mmHg, a higher starting dose of Entresto may be appropriate. In such cases, the typical starting regimen is 100 mg twice daily—100 mg in the morning and 100 mg in the evening. This dosage may be fine-tuned over time depending on how the patient responds, particularly in terms of blood pressure stability and heart failure symptoms.

Regular follow-ups with a healthcare provider are essential to ensure that the medication is working effectively and that any side effects, especially hypotension, are managed properly. Adjustments to the dosage should always be made under medical supervision to optimize heart failure treatment and maintain safe blood pressure levels.